Teratogenicity of Carbamazepine
نویسندگان
چکیده
منابع مشابه
Characterization of carbamazepine metabolism in a mouse model of carbamazepine teratogenicity.
The disposition of carbamazepine (CBZ) was investigated in the SWV mouse. A 14C-CBZ dose was administered to CBZ pretreated mice, and the distribution of radiolabeled material was determined. Twenty-four hours after the 14C-CBZ dose, 92.5% of the dose was accounted for in urine (56%), in the visera and carcass (22%), in feces (11%), and expired as 14CO2 (2%). CBZ metabolites present in hydrolyz...
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Objective Antiepileptic drugs (AED) have chronic teratogenic effects, the most common of which are congenital heart disease, cleft lip/palate, urogenital and neural tube defects. The aim of our study is to examine teratogenic effects of AED and the correlation between these malformations and AED in single or multiple pregnancies. Methods This is a retrospective study of malformations in child...
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ژورنال
عنوان ژورنال: Pediatric Neurology Briefs
سال: 2001
ISSN: 2166-6482,1043-3155
DOI: 10.15844/pedneurbriefs-15-8-5